In Vitro Fertilization (IVF) | IVF Treatment Lahore

ivf treatment lahore

In vitro fertilization (IVF) is a widely used method of infertility treatment, in which conception does not occur in the woman’s body, but artificially, in a laboratory. Today, IVF is one of the standard methods of reproductive medicine, but the process requires serious preparation and takes a long time. In addition to hormonal stimulation, minor surgical intervention may be required.

Who is IVF suitable for?

Fertilization outside the body is carried out, for example, in the case of irreparable damage to the fallopian tubes, endometriosis, infertility caused by antibodies to the partner’s sperm, a slight limitation of the man’s ability to conceive, or the inability to find the cause of childlessness. The method is also suitable for couples diagnosed with male factor infertility, for example, sperm are not motile enough to fertilize an egg naturally.

A special form of IVF Treatment Pakistan is intracytoplasmic sperm injection (ICSI). Here, a reproductive medicine specialist injects a single sperm using a fine pipette under a microscope directly into the egg. In vitro fertilization itself is often the second step after ICSI treatment has not resulted in pregnancy.

How to prepare for IVF?

Before the actual treatment, the couple wishing to have children has a detailed discussion with the attending physician. Here you can ask all your questions and clarify the list of necessary preparatory procedures. In addition, you must complete applications for coverage by your health insurance company. Ultrasound and blood tests clarify the medical prerequisites for therapy.

Both partners take a current test for HIV, hepatitis B and hepatitis C (all results must be negative). The woman must provide proof of rubella vaccination.

Sperm examination

The man’s sperm are checked for quantity, motility, shape and possible infections. A spermogram can be used to determine whether he is capable of conception and to what extent. The man’s sperm undergoes special processing (washed and concentrated) and is placed in a cryochamber for freezing.

Hormonal treatment

IVF almost always requires hormonal treatment for the woman. For the simultaneous maturation of several eggs, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are administered. Both are also produced by the body to stimulate the ovaries. At the beginning of treatment, the so-called down-regulation is most often used, in which hormonal drugs suppress the secretion of estrogen in the woman’s body, thus preventing uncontrolled ovulation.

Depending on the ivf treatment lahore regimen, targeted hormonal stimulation of the ovaries begins no later than after 14 days. It is believed that it provokes the ovaries to mature several egg vesicles (follicles) at the same time. This increases the chances of obtaining several eggs capable of fertilization.

Egg puncture

Approximately 36 hours after the hCG trigger injection, the fertility specialist retrieves the eggs. To do this, he inserts a thin needle into the ovaries under visual control using vaginal ultrasound and selects eggs that are capable of fertilization.

Egg retrieval takes about 15-20 minutes and can be done under light anesthesia. After an observation period of two to four hours, the woman is allowed to return home. The procedure is usually performed through the vagina. In rare cases, eggs are retrieved using an abdominal puncture. If necessary, the woman will be prescribed sedatives or painkillers and a brief general anesthesia. After the puncture, slight bleeding and a feeling of soreness may occur.

Fertilization in the laboratory

On the day of egg retrieval, fresh or frozen sperm from the partner is required. In cases of serious fertility problems in men, sperm obtained through testicular biopsy and then cryopreserved can be promptly thawed.

Before the sperm and egg can be combined, the seminal fluid is processed in a laboratory. The goal is to improve the ability of sperm to fertilize and prevent possible allergic reactions in the woman. In the laboratory, a reproductive specialist selects mature eggs and places them in a test tube or Petri dish with a nutrient solution and pre-treated sperm. The eggs and sperm are then placed in an incubator.

The fact that a sperm has penetrated an egg can be determined under a microscope by two precursor cells that contain the genetic material of the sperm and the egg. At this prenuclear stage, eggs are selected that will later be transferred to the uterus. The rest are either destroyed or deep frozen. In this way, they can be used for possible further treatment without the need for repeated egg retrieval.

Transfer of embryos to the uterus

After successful fertilization, the cells divide and embryos are formed after two to three days. On days 2-6 after egg retrieval, the doctor transfers one to three embryos into the uterus. This is done using a thin, flexible tube (catheter) passed through the vagina. Implantation takes place on a gynecological chair and resembles a standard examination. For transfer, the doctor places the embryos in a special transfer cannula and implants them into the uterus under ultrasound guidance. It is painless, so no anesthesia is required.

In special cases, for example, after three unsuccessful embryo transfers or when frozen (cryopreserved) eggs at the prenuclear stage are thawed, an attempt can be made to improve the conditions for implantation of the transferred embryos. To do this, an incision is made on the outer membrane of the embryo using a laser device.

Control examinations

About 14 days after the transfer of one or more embryos into the uterus, it is possible to determine whether pregnancy has begun by the level of the hCG hormone in the blood. To be sure, the doctor will conduct several follow-up examinations. About a month after the transfer, ultrasound can determine whether the embryo is alive and whether the pregnancy is singleton or multiple.

Most doctors recommend that women rest for two days after the transfer and avoid overexertion. The couple should also observe sexual rest during this period. These measures are intended to facilitate implantation of the embryo into the uterus. To support implantation, a woman takes progesterone as prescribed by a doctor, and in some cases she is additionally given the pregnancy hormone hCG, depending on the size of the ovaries, the patient’s condition and the number of eggs retrieved. About two weeks after the transfer, a blood test will show whether the pregnancy is developing.

Are there age restrictions for IVF?

From a medical point of view, in vitro fertilization is possible throughout a woman’s entire fertile period. However, the success rate of IVF is on average about 30%. The success of fertilization, that is, a woman’s pregnancy and birth of a child, depends on the type and duration of the underlying fertility disorder, as well as the age of the patient. The likelihood of becoming pregnant with best ivf in lahore, as without it, decreases with age. Young women under the age of 30 have the best chance of successful IVF. With age, the number of eggs decreases and cycles without ovulation become more frequent. In addition, the likelihood of miscarriage increases significantly.

hormonal treatment is a serious burden for a woman, including psychological.

Risks of in vitro fertilization

Like any procedure, in vitro fertilization is associated with risks and side effects. Thus, in less than 1% of cases, follicular puncture is accompanied by complications such as pain, bleeding, damage to neighboring organs or infection.

5% of women experience ovarian hyperstimulation syndrome, which is potentially life-threatening. Symptoms include severe bloating, severe pain in the lower abdomen, significantly enlarged ovaries and fluid in the abdomen. However, overstimulation of the ovaries is highly treatable. Affected women require a lot of fluids, a gentle regimen, and injections to prevent thrombosis.

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